While normal littoral cells show minimal or variable histiocytic marker expression, LCA cells consistently exhibit dual endothelial and histiocytic differentiation.5,20 In addition, CD8 expression in normal littoral cells reflects the organized architecture of the splenic red pulp; consequently, the absence of CD8 expression, as demonstrated in this case, may indicate neoplastic disruption of normal splenic structure.20 Ultimately, the histology and the IHC results led to a definitive diagnosis as their descriptions matched the distinct histological features of LCA. The gene discussed is CD8A; the disease is Leber congenital amaurosis.