IDH1 and chronic myelomonocytic leukemia: The development of CMML is driven by somatic mutations in haematopoietic stem cells that can alter DNA methylation (TET2, DNMT3A, IDH1, IDH2), RNA splicing (SRSF2, SF3B1, U2AF1, ZRSR2), histone modification (ASXL1, EZH2), cell signalling (NRAS, KRAS, CBL, NF1, PTPN11, JAK2) and transcription factors (RUNX1, SETBP1, GATA2).7