Curcumin, resveratrol, and vitamin E were identified as potential therapeutic agents that act on PCOS mechanisms by targeting GSTP1. Insulin resistance (IR) is closely associated with PCOS and is one of the most prevalent endocrine disturbances in 75% of PCOS patients; IR is linked to PI3K and apoptosis signaling pathways [60, 61], and STAT3 may influence the metabolism of PCOS patients by impacting insulin signaling pathways and metabolic regulation. This evidence concerns the gene INS and Insulin resistance.