Since low expression of miR-29a-3p in FA cells suggests possible altered expression of genes involved in oxidative stress response (Fig. 1B), catalase (CAT) activity, and intracellular malondialdehyde (MDA) levels have been evaluated as markers of antioxidant defenses and oxidative damage, in FA cells transfected with miR-29a-3p. This evidence concerns the gene CAT and Friedreich ataxia.