IKZF1 and acute lymphoblastic leukemia: Comparative analysis of genome wide enrichment of H3K27me3 in normal and malignant human and mouse cells showed a remarkable conservation of H3K27me3 landscape in human and mouse thymocytes, loss of H3K27me3 in T-ALL, and an important role of IKAROS in maintaining H3K27me3 landscape (Fig. S22).