There is a dynamic shift in the function of the genes regulated by H3K27me3 LOCKs: in day #1 following IKAROS re-expression, H3K27me3 LOCKs regulate mostly pathways in cancer and cellular proliferation, while in day #2, H3K27me3 LOCKs mostly regulate genes involved in immune response (Fig. S16A, B). The gene discussed is IKZF1; the disease is cancer.