PLCG2 and autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation: Indeed, many of the somatic PLCG2 variants observed in the context of BTKi therapy overlap with those occurring in autoimmune PLCG2-associated immune dysregulation (APLAID), an inherited syndrome caused by germline gain-of-function PLCG2 variants [25].