Although the precise role of USP‐7 in cancer is not yet fully elucidated, its key involvement in regulating major cancer hallmarks and oncogenic pathways makes it an attractive and high‐value target for cancer therapy.[10] The identification of novel USP‐7 inhibitors endowed with an unreported chemical structure, low micromolar potency, excellent permeability, and absence of toxicity contributes to clarify the role of this enzyme in carcinogenesis and provide the basis for future studies to identify more effective USP‐7 pyrazole blockers. This evidence concerns the gene USP7 and cancer.