In theory, therefore, an intriguing mechanistic concept could be that PARPi modify tumor cells to become more susceptible to CD8+ T cell and NK cell killing during the lytic attack mediated by their cytotoxic granule exocytosis, which in turn intensifies GSDM-induced ICD signaling and generates a positive feed-forward loop towards augmented tumor cell immunogenicity (figure 1). The gene discussed is GSDMA; the disease is neoplasm.