<h4>Objective</h4>We aim to explore the diagnostic value of early detection of serum stromal interaction molecule 1 (STIM1), advanced oxidation protein products (AOPPs), urinary neutrophil gelatinase-associated lipocalin (NGAL), and angiotensinogen (AGT) in hypertensive nephropathy (HN).<h4>Methods</h4>A retrospective study was conducted on 123 patients with primary hypertension. This evidence concerns the gene STIM1 and essential hypertension.