After correcting for multiple comparisons (FDR-corrected p < 0.05), the only phenotypes significantly associated with higher genetically proxied monocyte-specific LIPA expression in the PheWAS analyses were myocardial infarction, coronary atherosclerosis, and ischemic heart disease, thereby validating the relevance of LIPA in monocytes for ASCVD in an external dataset (Figure 4B; Table S13). Here, LIPA is linked to coronary atherosclerosis.