,38,39 Additionally, we identified previously underrecognized ASCVD risk associations of several genes, such as the CD4NC cell-specific effect of the poorly characterized gene DDTL. While the expression of genes such as COG5 and ZFP57 was found to affect disease risk in multiple immune cell types, higher genetically proxied expression of LIPA was associated with a higher risk of two ASCVD outcomes—CAD and LAS—specifically in monocytes. Here, DDTL is linked to atherosclerosis.