In patients with lupus erythematosus, an intense expression of AIM-2 was observed in macrophages, possibly due to decreased DNA methylation in these individuals, contributing to the pathogenesis of the disease.90, 91 Moreover, in lesions from patients with lichen planus, there is a specific increase in the AIM-2 protein in both the dermis and the epidermis, with improved dermal expression of the IL-1β protein.92 This evidence concerns the gene AIM2 and lichen planus.