The expression of NLRP1 and NLRP3 receptors is also increased in the damaged skin of AD patients and is directly associated with the severity of the disease, highlighting the importance of this signaling cascade for the inflammatory pathology of this and other skin diseases.70, 98, 100 In 2010, Grigoryev et al.,100 showed that NLRP1 gene expression is inversely correlated with AD severity in skin explants, suggesting that local inflammation could inhibit NLRP1 expression, or that reduced expression of this protein promotes skin inflammation. Here, NLRP1 is linked to Alzheimer disease.