Other tumor suppressor genes frequently hypermethylated in melanoma include phosphatase and TENsin homolog (PTEN), ADP Ribosylation Factor 1 (ARF1) and RAS association domain family protein 1 (RASSF1A) [[26], [27], [28]], Cadherin 1 (CDH1), PDZ And LIM Domain 4 (PDLIM4), Heart And Neural Crest Derivatives Expressed 1 (HAND1), NK2 Homeobox 3 (NKX2–3), Oligodendrocyte Transcription Factor 2 (OLIG2), O-6-Methylguanine-DNA Methyltransferase (MGMT), Cadherin 13 (CDH13), Retinoic Acid Receptor Beta (RARβ2), Paired Box 2 (PAX2) and Paired Box 7 (PAX7) [29], as well as other genes. The gene discussed is NKX2-3; the disease is melanoma.