EZH2 and melanoma: Similarly, specific lncRNAs such as ANRIL, CASC15, LNMAT1, MIRAT, THOR, TTN-AS1, CDR1a, DIRC3 and GAS5 modulate critical melanoma-associated genes, including CDKN2a/b, Programmed Cell Death 4 (PDCD4), Cell Adhesion Molecule 1 (CADM1), MAPK, Insulin Like Growth Factor 2 MRNA Binding Protein 1 (IGF2BP1) and Titin (TTN), Insulin Like Growth Factor 2 MRNA Binding Protein 3 (IGF2BP3), Insulin Like Growth Factor 2 MRNA Binding Protein 5 (IGFBP5) and Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit (EZH2) [42].