While prolonged heat exposure has been shown to negatively impact inflammatory responses, gastrointestinal barrier integrity, and body core temperature regulation, particularly in older adults and those with HTN and T2D (McCormick et al., 2023; Lee et al., 2024; Meade et al., 2023), the stability of irisin and betatrophin suggests that these metabolic hormones may play a more sustained, long‐term role in baseline metabolic regulation rather than responding acutely to heat stress. The gene discussed is ANGPTL8; the disease is type 2 diabetes mellitus.