In line with previous work (McCormick, King, Notley, Fujii, Boulay, Sigal, Amano, & Kenny, 2022), the fact that irisin levels were not significantly different between older adults with and without HTN or T2D suggests that age‐related declines in irisin may be independent of metabolic disease status. This evidence concerns the gene FNDC5 and hypertensive disorder.