Significant differences between MCI with awareness vs MCI with anosognosia in clinical features were HADS-Depression (t = −3.2, df = 98, p = 0.001), and HADS-Anxiety (t = −2.6, df = 98, p = 0.009) scores, while differences in biomarkers were limited to GFAP (t = −2.2, df = 90, p = 0.033). Here, GFAP is linked to major depressive disorder.