In the subgroup analysis, elevated PDPN was a significant risk factor for OS in the female subgroup, HR (95% CI)=8.708(3.88,19.547), and in the male subgroup, elevated PDPN was a significant risk factor for OS, HR (95% CI)=4.339(2.704, 6.962); The P value for the interaction test was 0.203, indicating that there was no significant interaction of gender on the “association between PDPN and patient OS”, and the P value for the interaction test was 0.203, indicating that there was no significant interaction of gender on the poor prognosis of patients with high-grade gliomas. Here, PDPN is linked to glioma.