In recent years, multiple genetic risk factors related to AD have been identified, including ADAM33, RETN, TGFB1, CD207, TSLP, IL-13, IL-4, IL-31, IL6R, STAT3, KIF3A, and HLA-DBQ1, among others13, 22, 23, 24, 25, 26, 27 (Table 4). This evidence concerns the gene IL4 and Alzheimer disease.