SLC6A8 and cerebral creatine deficiency syndrome: We note that, based on the fact that such compounds can rescue multiple SLC6 transporters, atypical inhibitors could potentially offer therapeutic utility for the rescue of pathogenic SLC6A8 creatine transporter variants, the misfolding of which causes an X-linked neurological disorder known as cerebral creatine deficiency syndrome (61, 62, 63, 64).