A further noteworthy observation is that a significant number of DEPs (7 out of 72 proteins) have been implicated in syndromic and pathological myopias in these vitreous samples with PS, including S-arrestin, versican, lumican, dystroglycan 1, IRBP, and collagen IX α2, which is associated with Stickler syndrome (Supplemental Table 1). The gene discussed is VCAN; the disease is Stickler syndrome.