LRP2 and myopia: Variants in the gene encoding low-density lipoprotein (LDL) receptor–related protein 2 (LRP2) cause the rare Donnai-Barrow syndrome (DBS, OMIM 222448), which combines pathologic myopia and PS, hypertelorism, craniofacial malformations, sensorineural hearing loss (SHL), agenesis of the corpus callosum (ACC), and proteinuria (12–14).