In vehicle-treated mice, the majority of tumor cells grouped into cluster 1 and had characteristics of prostate adenocarcinoma, including luminal markers KRT8, KRT18, FOLH1; prostate transcription factors AR, NKX3-1, FOXA1, HOXB13; and GI transcription factors HNF1A, HNF4G, and downstream target like MUC13 (Supplemental Figure 6A). The gene discussed is NKX3-1; the disease is neoplasm.