We demonstrate that, unlike the case for most other tumors, human lung adenocarcinoma and murine models of lung cancer are enriched for type 1 proinflammatory cytokines, such as IFN-γ and TNF-α, when compared with other malignancies, including melanoma, colon, and pancreatic cancers. The gene discussed is IFNG; the disease is familial pancreatic carcinoma.