CD8A and neoplasm: As expected, and consistent with the role of CD8+ T cells in immunosurveillance and control of tumor growth, B6CD8–/– mice had a higher incidence of malignancy and a higher tumor burden than wild-type B6 mice (Supplemental Figure 1A; supplemental material available online with this article; https://doi.org/10.1172/JCI191070DS1).