These have focussed mainly on the production of gastrin that can be associated with Zollinger-Ellison syndrome and multiple endocrine neoplasia type 1 (MEN1) syndrome (15–17) or of somatostatin (18) that may be associated with a unique psammomatous tumor in patients with neurofibromatosis (19). The gene discussed is GAST; the disease is Zollinger-Ellison syndrome.