Immune checkpoint inhibitors illustratesthe success of antibodies and mimics thereof. Tumor cells avoid destruction by T cells by engaging its programmedcell death protein 1 (PD1) with the tumor cells’ programmedcell death protein ligand 1 (PD-L1). Complexationof PD-1 to PD-L1, signals the T cell to spare the target cell, allowingthe tumor to evade the immune system. The gene discussed is CD274; the disease is neoplasm.