CD274 and adenocarcinoma: Post hoc IHC analyses of TIM-3 and PD-L1 expression in pretreatment tumor samples showed TIM-3 and PD-L1 expression was similar between adenocarcinoma and squamous cell histologies; however, although PD-L1 expression was not associated with observed response, pretreatment TIM-3 levels were significantly greater for patients with an observed response than for patients with progressive disease.