A missense mutation in PSMB8, G197E, results in the reduced expression of PSMB8, elevated IL-6 production, and lipodystrophy through disturbed adipocyte differentiation, high-level neutrophilia in the dermis, and accumulation of ubiquitinated proteins in PSMB8 mutated cells (157, 158). Here, PSMB8 is linked to lipodystrophy.