HOTAIR and melanoma: Notably, dysregulated expression of lncRNAs such as MALAT1, HOTAIR, and SAMMSON has been associated with melanoma metastasis, invasion, and resistance to chemotherapy (6, 10, 11) These lncRNAs function as oncogenic drivers by promoting tumor cell proliferation, migration, and epithelial–mesenchymal transition; however, our common understanding remains far from complete.