TGFB2 and open-angle glaucoma: Strain and shear stress have been hypothesized to engage primary cilia and integrins, as well as mechanosensitive TRPV4, Piezo1, and TREK-1 channels (Luo et al., 2014; Ryskamp et al., 2016; Yang et al., 2022; Yarishkin et al., 2021), yet it remains unclear whether these mechanosensors regulate TM contractility, are influenced by POAG inducers like TGFβ2 or glucocorticoids, or contribute to chronic fibrosis.