TGFβ2-induced fibrotic remodeling has been linked to POAG: (1) TM cells derived from POAG patients secrete more active TGFβ2 compared to cells isolated from healthy donors (Li et al., 2022b), (2) the risk of POAG is proportional to [TGFβ2]AH (Agarwal et al., 2015; Ochiai and Ochiai, 2002; Tripathi et al., 1994), and (3) ectopic ocular expression of TGFβ2 suffices to induce OHT (Patil et al., 2022; Shepard et al., 2010), likely via aberrant secretion of ECM proteins and enhanced TM contractility (Fleenor et al., 2006; Montecchi-Palmer et al., 2017). The gene discussed is TGFB2; the disease is open-angle glaucoma.