The upregulation of TRPV4/PIEZO1 transcription by TGFβ2 predicts exaggerated responsiveness of the outflow pathway to mechanical loading, as reported for TRPV4-dependent mechanical hyperalgesia in chemotherapy (Matsumura et al., 2014), neuropathic pain (Zhang et al., 2008b; Alessandri-Haber et al., 2006), cancer (Maqboul and Elsadek, 2018), and diabetic neuropathy (Cui et al., 2020). Here, PIEZO1 is linked to cancer.