Strain and shear stress have been hypothesized to engage primary cilia and integrins, as well as mechanosensitive TRPV4, Piezo1, and TREK-1 channels (Luo et al., 2014; Ryskamp et al., 2016; Yang et al., 2022; Yarishkin et al., 2021), yet it remains unclear whether these mechanosensors regulate TM contractility, are influenced by POAG inducers like TGFβ2 or glucocorticoids, or contribute to chronic fibrosis. The gene discussed is TRPV4; the disease is open-angle glaucoma.