The etiology of glaucoma reflects convergence of risk factors that include IOP and TGFβ2: epidemiological data correlate the incidence of POAG with the amplitude of IOP and [TGFβ2]AH (Tripathi et al., 1994; Leske et al., 2003), while chronic increases of either [TGFβ2]i or IOP promote fibrotic remodeling of TM/SC and augment the flow resistance of the conventional pathway (Fuchshofer and Tamm, 2012; Shepard et al., 2010; Fleenor et al., 2006). The gene discussed is TGFB2; the disease is open-angle glaucoma.