Regarding the relationship between genetic alterations and serine dependency, acute myeloid leukemia (AML) with internal tandem duplication of the FMS‐like tyrosine kinase 3 gene (FLT3‐ITD) exhibits metabolic vulnerability in de novo serine synthesis, and PHGDH inhibition by PKUMDL‐WQ‐2101 sensitized FLT3‐ITD AMLs to cytarabine, a standard chemotherapeutic agent [32]. The gene discussed is FLT3; the disease is acute myeloid leukemia.