Moreover, even in tumor models without MTAP deletion, pharmacological inhibition of MTAP using methylthio‐DADMe‐immucillin‐A (MTDIA) successfully induced an MTAP‐depleted state in colorectal cancer cells, and the combination of MTDIA and the MAT2A inhibitor AG‐270 exhibited synthetic lethality [37]. The gene discussed is MTAP; the disease is neoplasm.