PIK3CA and breast carcinoma: In that study, iKnife analysis revealed that mutated PIK3CA in breast cancer cells led to increased production of arachidonic acid through activation of calcium‐dependent cytosolic phospholipase A2 (cPLA2), and that inhibiting cPLA2, combined with a fat‐free diet, suppressed tumor growth in breast cancer harboring PIK3CA mutations [46].