Among the tested 11 biomarkers at baseline, Ssc5D and IGFBP7 are particularly noteworthy as they showed the highest correlation coefficients with NITs at follow‐up and their concentrations at baseline were significantly correlated with FIB4, LSM and ELF at follow‐up, therefore increasing the likelihood that they are reliable predictive markers for liver fibrosis development. The gene discussed is IGFBP7; the disease is Hepatic fibrosis.