Translating to human in a second step, with a selection of participants at risk for MASLD from a longitudinal general population study with a median follow‐up of 7 years, we found that baseline serum concentrations of five of these markers, being Sema4D, Ssc5D, VCAN, THBS1 and IGFBP7 correlated with the liver fibrosis proxy FIB4 at follow‐up; that three of these markers, being TNC, Ssc5D and IGFBP7 correlated to LSM at follow‐up, and that two of these markers at baseline, being Ssc5D and IGFBP7 correlated to ELF at follow‐up. Here, SEMA4D is linked to Hepatic fibrosis.