For instance, in gastric cancer, fibroblast subpopulations have been shown to interact with EC‐ESM (tip‐like endothelial) cells to enhance blood vessel formation.[53] Taken together, our data suggest that the MMP11+ mCAF subpopulation may enhances the migratory capacity of the ESM+ tEC cells via the WNT5A‐MCAM signaling axis, thereby potentially facilitating angiogenesis. The gene discussed is MCAM; the disease is gastric cancer.