TGFB1 and cancer: For instance, TGF‐β family ligands are key drivers of fibroblast activation, with TGFB1 considered a primary stimulator of myofibroblast differentiation.[60, 61, 62, 63] Conversely, IL‐1 is a known inducer of inflammatory fibroblasts.[9, 64] Therefore, selective elimination or remodeling of specific CAFs subpopulations, or inhibition of downstream signaling pathways in CAFs, may represent effective therapeutic strategies in cancer treatment.