MMP11 and neoplasm: Previous studies have established that VEGFA is essential for the formation of tip cells and the extension of filopodia, which are crucial for the migration of endothelial cells.[56, 57, 58, 59] Taken together, our findings suggest that MMP11+ mCAFs can induce the formation and migration of tip endothelial cells both directly and indirectly, thereby contributing to tumor angiogenesis.