The anti‐inflammatory and pro‐tumorigenic effects of M2‐like macrophages are well‐documented but fail to capture the full complexity of macrophage activation states.[38] In this study, we identified two distinct macrophage populations in iCCA: pro‐tumor TREM2+ macrophages and anti‐tumor CD5L+ macrophages, further clarifying the spectrum of macrophage phenotypic plasticity in TME remodeling. Here, CD5L is linked to neoplasm.