Among them, CD8+ T cells play a pivotal role in anti‐tumor immunity by mounting effective immune responses against tumors.[23] However, immunosuppressive cells such as TAMs and myeloid‐derived suppressor cells often suppress CD8+ T cell function, thereby facilitating tumor progression in various cancers, including hepatocellular carcinoma.[24] To investigate the effects of TNTs‐mediated material transfer on macrophage function, we evaluated three key parameters: macrophage phagocytic activity, their regulatory effects on CD8+ T cell proliferation, and their pro‐tumorigenic capacity. Here, CD8A is linked to cancer.