TNTs are not exclusive to iCCA; they are widely present in cancers such as breast, lung, and pancreatic cancers, primarily facilitating cancer cell‐to‐cell communication.[20] This study is the first to highlight their role in tumor‐immune cell interactions in iCCA, raising the possibility that TNTs may mediate similar immunosuppressive effects in other cancers, such as hepatocellular carcinoma and pancreatic cancer. Here, PRRT2 is linked to neoplasm.