As expected, the HF diet contributed to a decrease in WAT and BAT metabolism, characterized by decreased OCR in WAT in basal conditions and in response to the catecholaminergic mediators NE and dopamine, as well as to a decrease in thermogenesis markers and a reduction in the levels of PGC1α and PPARγ, critical regulators of mitochondrial biogenesis. The gene discussed is PPARG; the disease is hydrops fetalis.