These effects are amplified by placental‐maternal interactions: anemia (hemoglobin < 110 g/L) or inflammation (hs‐CRP > 3 mg/L) reduces maternal‐fetal vitamin A transport efficiency by 40% (Plunkett et al. 2012), forcing a “thrifty phenotype” adaptation that prioritizes brain development over body composition equilibrium (PI reduction: 0.23 kg/m3) (Leigh and Kaynak 2020). The gene discussed is CRP; the disease is anemia.