To further explore the specific mechanisms of the co‐localized variant target gene FTO and the mediator protein DNER‐regulated genes in NAFLD, we performed multiple bioinformatics analyses of DNER and FTO using the NAFLD sample RNA sequencing dataset GSE260666 and the single‐cell sequencing dataset GSE202379. The gene discussed is FTO; the disease is metabolic dysfunction-associated steatotic liver disease.