CASP1 and Parkinson disease: Key signaling pathways involved in inflammasome activation in microglial cells during Parkinson’s disease progression include TLRs/NF-κB/NLRP3, TLR/NLRP3/Caspase-1, and NF-κB/AP-1/Nrf2 (Zhou et al., 2016; Gordon et al., 2018; Lee et al., 2019).