In diseases such as obesity, a high frequency of haplotypes such as AGAC, GGAC, and AAAC has been observed, which correspond to SNPs of the TLR4 gene (A-2570G position 1, G-2081A position 2, A896G position 3, and C1196T position 4). The gene discussed is TLR4; the disease is obesity due to melanocortin 4 receptor deficiency.