This study is in line with the research of Al-koshabet al. that reported thatFicus deltoidea extract could significantly reduce the tongue tumor volume of OSCC at a high dose of 500 mg/kg BW and decreased the expression of key tumor marker cyclin D1 and increased β-catenin and e-cadherin antibodies.34 Another study conducted by Roy Met al. uses black tea extract to prevent carcinogenesis by down-regulating protein tyrosine kinases, reducing ROS level in blood, and resolving DNA damage.42 This evidence concerns the gene CCND1 and neoplasm.