CHMP5 and infection: Collectively, revaccination of hybrid-immune individuals leverages key humoral immune features that are likely key for protection against infection and disease: rapid affinity maturation and clonal diversification, enabling the rapid adaptation and updating of the humoral immune response for the most current viral variant (120, 131, 132), and expansion of functional humoral immunity to the whole surface of the Spike antigen, resulting in a highly resilient immune response able to rapidly capture and clear the infection (22).