In atopic dermatitis (AD), BNP is released from skin peripheral nerve endings after IL-31 secretion by Th2 cells, and contributes to itch formation, and activates keratinocytes to increase IL17A, CXCL10, and MMP9 production and acts on dendritic cells (DCs) to produce CCL20 (15). Here, NPPB is linked to Alzheimer disease.