↑ Cytotoxicity in vitro in SETD2-deficient ccRCC cell lines;↑apoptosis; ↑ DNA damage; ↓insufficient DNA damage repair;↑genomic instability;↑immune responses;↑STING;↑ viral mimicry by activating transposable elements; ↓ growth of SETD2-deficient ccRCC in in vivo. This evidence concerns the gene SETD2 and nonpapillary renal cell carcinoma.