We observed a significant downregulation of NKG2D ligands, such as MICA, MICB and ULPB1, 2, and 3 following BET/JQ1treatment of the human tumor cells (Figure 8) with similar findings noted in mouse N2a treated cells as well (Ulbp1, Rae1a and Rae1b) (Figure 8). This evidence concerns the gene KLRK1 and neoplasm.