MICA and neoplasm: We observed a significant downregulation of NKG2D ligands, such as MICA, MICB and ULPB1, 2, and 3 following BET/JQ1treatment of the human tumor cells (Figure 8) with similar findings noted in mouse N2a treated cells as well (Ulbp1, Rae1a and Rae1b) (Figure 8).