APOB and atherosclerosis: The response-to-retention hypothesis of atherosclerosis states that atherogenesis is triggered by the subendothelial retention of Apolipoprotein B (ApoB)-containing lipoproteins such as low-density lipoprotein (LDL), lipoprotein (a) (Lp(a)), and, triglyceride-rich lipoproteins, including the dietary-derived chylomicron remnants (1, 4, 5).