TMEM115 and central nervous system cancer: Knockdown of TMEM115 significantly reduced the protein expression of glioma cells compared to those infected with negative controls (Figures 3A, B) The results of the CCK-8 assay showed that the proliferative capacity of U87MG and U251 cells was significantly decreased with the reduction of TMEM115 levels (Figures 3C, D) Subsequently, using Transwell assay assessment, after TMEM115 downregulation, the migration and invasion abilities of U87MG and U251 glioma cells were inhibited (Figures 3E-J).