Furthermore, given the new definition of adult gliomas in the 2021 WHO classification, we investigated the expression of TMEM115 in IDH mutation astrocytoma, IDH mutation, and 1p19q codeletion oligodendroglioma, and IDH wild-type glioblastoma (P < 0.05) (Figure 1D). Here, TMEM115 is linked to astrocytoma (excluding glioblastoma).