In acute myeloid leukemia, It has been shown REV increased the expression of hsa-miR-335-5p while decreased the expression of NFS1 and GPX4; it increased ferroptosis in AML cells through the Hsa-miR-335-5p/NFS1/GPX4 pathway in a manner dependent on ROS (162). The gene discussed is GPX4; the disease is acute myeloid leukemia.