TP53 and cancer: In terms of mechanism, CUR triggered ferroptosis and inhibited the proliferation of cancer cells via the inhibition of the PI3K/Akt/mTOR signaling pathway (102), dual suppression of GPX4 and FSP1 (103), suppression of JNK signaling (104), and regulation of P53 and the SLC7A11/GHS/GPX4 axis (105).