The highest pCR rates were found in HER2-positive breast cancers, followed by tumors with HER2-zero and HER2-low (pCR rates in HER2-positive vs. HER2-zero vs. HER2-low: 57.0% vs. 33.7% vs. 15.4%, P < 0.001; Figure 1C). The gene discussed is ERBB2; the disease is breast carcinoma.