STING1 and pancreatic ductal adenocarcinoma: Another study published in “Nature Biotechnology” utilized CRISPR-edited Salmonella to deliver nanodrugs, degrading the tumor ECM and activating the STING pathway, enhancing the permeability and immunogenicity of chemotherapy drugs in pancreatic ductal adenocarcinoma, resulting in a 2.3-fold extension of survival in the combination therapy group (87).