In these patients, univariate analysis showed that clinicopathological factors associated with worse DFS were age (p=0.031), Ki67 expression (p<0.001), higher cN stage (p=0.01), higher Clinical stage at diagnosis (p<0.001), higher tumor grade (p<0.001), and higher tumor grade (p<0.001), Chemotherapy (p=0.035), ypN stage (p<0.001) and ypTNM (p<0.001) and lower PCR (p=0.008) (Figure 2A). This evidence concerns the gene MKI67 and neoplasm.