In Additional Model 4, after adjusting for age, STEMI, Killip class, hypertension, diabetes, AF, antihypertensive drugs, antidiabetic drugs, SBP, FPG, eGFR, BNP, and multivessel disease, Lp(a) remained an independent predictor of MACE, with significantly elevated HRs across both categorical and continuous variable analyses (all P < 0.05). This evidence concerns the gene NPPB and diabetes mellitus.