TNF-α, IL-6, and interleukin-1 beta (IL-1β) are proinflammatory cytokines that work in a vicious cycle with NF-κB signaling pathways to promote one another and intensify the inflammatory response, causing liver fibrosis (Hoesel and Schmid, 2013; Sun, 2017). The gene discussed is IL1B; the disease is Hepatic fibrosis.