ACTA1 and Hepatic fibrosis: By blocking the NF-κB signaling pathway, liver tissue can exhibit reduced expression of proinflammatory cytokines (IL-6 and TNF-α), in addition to decreased collagen deposition, fibrosis marker α-SMA expression, and liver fibrosis (Luedde and Schwabe, 2011; Aoyama et al., 2021).