In JADER, five SOCs showed positive signal values, including “blood and lymphatic system disorders” (ROR 4.43, 95% CI: 4.26–4.61), “gastrointestinal disorders” (ROR 2.57, 95% CI: 2.46–2.68), “investigations” (ROR 1.98, 95% CI: 1.90–2.07), “respiratory, thoracic, and mediastinal disorders” (ROR 1.14, 95% CI: 1.07–1.21), and “metabolism and nutrition disorders” (ROR 1.55, 95% CI: 1.45–1.65) (Figure 2F). Here, CISH is linked to lymphatic system disorder.