It was found that knockdown of Fatp2 in mice reduced the ability of hepatocytes to uptake peripheral circulating FFA by 40%, and Fatp2−/− mice did not develop hepatic steatosis compared to normal mice that also consumed high-fat diet (HFD) and already had developed NAFLD (Falcon et al., 2010). This evidence concerns the gene SLC27A2 and metabolic dysfunction-associated steatotic liver disease.