In summary, in early NAFLD, promoting CPT1 expression helps to promote FAO to reduce intrahepatic lipids, while enhancing CPT1 accelerates the process of hepatic fibrosis when NAFLD shifts to hepatic fibrosis, thus intervening CPT1 at different stages of NALFD may reap completely opposite results. This evidence concerns the gene CPT1A and metabolic dysfunction-associated steatotic liver disease.