A study on Alzheimer’s disease (AD) (Haney et al., 2024) found that ACSL1 is the most important lipid synthesis gene for the formation of LD from TG in microglia in brain tissue, and overexpression of ACSL1 induced the synthesis of LD from TG in brain tissue, and the inhibition of ACSL1 attenuated the accumulation of LD in brain tissue, but further studies are needed to find out whether it also has such a role in the liver. This evidence concerns the gene ACSL1 and early-onset autosomal dominant Alzheimer disease.